Xiaodong Han Selected Research

cyanoginosin LR (microcystin LR)

9/2022	Movement Disorder and Neurotoxicity Induced by Chronic Exposure to Microcystin-LR in Mice.
4/2022	Male reproductive toxicity induced by Microcystin-leucine-arginine (MC-LR).
4/2022	Microcystin-leucine arginine (MC-LR) induces mouse ovarian inflammation by promoting granulosa cells to produce inflammatory cytokine via activation of cGAS-STING signaling.
11/2021	Chronic MC-LR exposure promoted Aβ and p-tau accumulation via regulating Akt/GSK-3β signal pathway.
4/2021	The mechanisms of mitochondrial dysfunction and glucose intake decrease induced by Microcystin-LR in ovarian granulosa cells.
2/2021	Higher content of microcystin-leucine-arginine promotes the survival of intrahepatic cholangiocarcinoma cells via regulating SET resulting in the poorer prognosis of patients.
1/2021	Chronic exposure to microcystin-LR increases the risk of prostate cancer and induces malignant transformation of human prostate epithelial cells.
12/2020	Microcystin-leucine-arginine induces liver fibrosis by activating the Hedgehog pathway in hepatic stellate cells.
11/2019	Blood-brain barrier disruption and inflammation reaction in mice after chronic exposure to Microcystin-LR.
1/2019	piRNA-DQ722010 contributes to prostate hyperplasia of the male offspring mice after the maternal exposed to microcystin-leucine arginine.

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Xiaodong Han Research Topics

Disease

27	Neoplasms (Cancer) 06/2022 - 01/2005
17	Pulmonary Fibrosis (Fibrosing Alveolitis) 05/2022 - 02/2014
13	Obesity 01/2022 - 11/2014
12	Type 2 Diabetes Mellitus (MODY) 01/2022 - 11/2014
10	Inflammation (Inflammations) 04/2022 - 02/2009
8	Fibrosis (Cirrhosis) 01/2021 - 08/2014
6	Renal Cell Carcinoma (Grawitz Tumor) 01/2022 - 01/2021
5	Weight Loss (Weight Reduction) 01/2020 - 12/2011
5	Body Weight (Weight, Body) 01/2020 - 11/2010
5	Necrosis 01/2017 - 01/2008
4	Neoplasm Metastasis (Metastasis) 06/2022 - 03/2012
4	Prostatic Neoplasms (Prostate Cancer) 01/2021 - 04/2016
4	Colorectal Neoplasms (Colorectal Cancer) 01/2020 - 07/2012
3	Memory Disorders (Memory Loss) 09/2022 - 01/2019
3	Idiopathic Pulmonary Fibrosis 01/2021 - 08/2014
3	Infections 08/2019 - 01/2014
3	Breast Neoplasms (Breast Cancer) 01/2018 - 07/2012
3	Obstructive Sleep Apnea 12/2016 - 08/2015
3	Lung Injury 01/2016 - 02/2014
3	Mucositis 12/2011 - 11/2010
3	Diarrhea 12/2011 - 11/2010
2	Wounds and Injuries (Trauma) 04/2022 - 08/2015
2	Alzheimer Disease (Alzheimer's Disease) 11/2021 - 01/2019
2	Anemia 11/2021 - 03/2016
2	Mitochondrial Diseases (Mitochondrial Disease) 04/2021 - 10/2008
2	Hypoxia (Hypoxemia) 01/2021 - 01/2014
2	Insulin Resistance 01/2020 - 11/2014
2	Carcinogenesis 01/2020 - 02/2016
2	Hyperplasia 01/2019 - 01/2017
2	Endometriosis 01/2019 - 01/2019
2	Lung Diseases (Lung Disease) 11/2018 - 02/2015
2	Stroke (Strokes) 09/2017 - 11/2011
2	Acute Lung Injury 09/2017 - 02/2009
2	Melanoma (Melanoma, Malignant) 04/2017 - 02/2016
2	Shock 07/2016 - 02/2009
2	Diabetes Mellitus 03/2016 - 11/2011
2	Lymphatic Metastasis 03/2016 - 07/2012
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 03/2016 - 01/2016
2	Infertility (Sterility) 12/2015 - 03/2004
2	Hypertension (High Blood Pressure) 07/2013 - 11/2011
1	Movement Disorders (Movement Disorder) 09/2022
1	Parkinson Disease (Parkinson's Disease) 09/2022
1	Bites and Stings (Sting) 04/2022

Drug/Important Bio-Agent (IBA)

19	Proteins (Proteins, Gene)FDA Link 09/2022 - 02/2009
13	cyanoginosin LR (microcystin LR)IBA 09/2022 - 10/2017
12	CateninsIBA 05/2022 - 02/2014
10	Bleomycin (Blenoxane)FDA LinkGeneric 01/2021 - 08/2014
6	CytokinesIBA 04/2022 - 01/2014
5	Messenger RNA (mRNA)IBA 09/2021 - 03/2012
5	Biological ProductsIBA 01/2020 - 10/2012
4	N-methyladenosineIBA 06/2022 - 01/2021
4	Piwi-Interacting RNAIBA 12/2020 - 07/2017
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 03/2020 - 01/2008
3	Hormones (Hormone)IBA 01/2022 - 01/2017
3	Transcription Factors (Transcription Factor)IBA 11/2021 - 12/2020
3	Glucose (Dextrose)FDA LinkGeneric 04/2021 - 01/2020
3	ChemokinesIBA 03/2020 - 12/2012
3	Interleukin-6 (Interleukin 6)IBA 03/2020 - 10/2010
3	MicroRNAs (MicroRNA)IBA 03/2020 - 01/2016
3	Therapeutic UsesIBA 12/2016 - 11/2010
3	Fluorouracil (Carac)FDA LinkGeneric 12/2011 - 11/2010
3	Pharmaceutical PreparationsIBA 08/2011 - 11/2009
2	6-methyladenineIBA 06/2022 - 01/2021
2	IronIBA 11/2021 - 06/2014
2	Apoptosis Regulatory ProteinsIBA 02/2021 - 03/2017
2	Caspase 8 (Caspase-8)IBA 02/2021 - 03/2017
2	MethyltransferasesIBA 01/2021 - 04/2016
2	LigandsIBA 01/2021 - 02/2012
2	Small Interfering RNA (siRNA)IBA 01/2021 - 01/2018
2	Phosphotransferases (Kinase)IBA 01/2021 - 01/2019
2	InflammasomesIBA 01/2021 - 03/2020
2	OsteopontinIBA 01/2021 - 02/2012
2	MagnesiumIBA 01/2021 - 12/2016
2	CollagenIBA 01/2021 - 01/2019
2	ElementsIBA 12/2020 - 01/2019
2	CXC ChemokinesIBA 03/2020 - 12/2012
2	activin AIBA 01/2019 - 02/2012
2	Caspase 3 (Caspase-3)IBA 03/2017 - 10/2012
2	Estrogens (Estrogen)FDA Link 01/2017 - 03/2004
2	CholesterolIBA 12/2016 - 07/2013
2	Triglycerides (Triacylglycerol)IBA 12/2016 - 07/2013
2	Indicators and Reagents (Reagents)IBA 11/2014 - 07/2012
2	Chemokine ReceptorsIBA 12/2012 - 07/2012
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 02/2012 - 01/2005
2	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 08/2011 - 11/2010
2	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 08/2011 - 11/2010
1	alpha-SynucleinIBA 09/2022
1	Tyrosine 3-Monooxygenase (Tyrosine Hydroxylase)IBA 09/2022
1	Dopamine (Intropin)FDA LinkGeneric 09/2022
1	Dopa DecarboxylaseIBA 09/2022
1	Dopamine Plasma Membrane Transport Proteins (Dopamine Transporter)IBA 09/2022
1	Wnt ProteinsIBA 05/2022
1	Mitochondrial DNA (mtDNA)IBA 04/2022

Therapy/Procedure

20	Therapeutics 01/2022 - 01/2005
15	Gastric Bypass (Roux-en-Y Gastric Bypass) 01/2022 - 11/2014
6	Bariatric Surgery 01/2020 - 01/2015
5	Drug Therapy (Chemotherapy) 09/2017 - 11/2010
2	Radiotherapy 01/2022 - 02/2016
2	Glycemic Control 01/2020 - 03/2016
2	Vitrectomy 08/2015 - 03/2014